indacaterol translation and audio pronunciation Pronunciation: In da KA ter ol. Ultibro Breezhaler is a medicine that contains two active substances, indacaterol (85 micrograms) and glycopyrronium (43 micrograms). Indacaterol inhalation is for use only in people with chronic obstructive pulmonary disease (COPD) and should not be used to treat asthma. In Definition 2 (D2), a $1-unit decrease in transition dyspnea index replaced FEV1. Either increases toxicity of the other by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Plasma concentrations of indacaterol and mometasone increase with repeated once-daily dosing; steady state is reached within 12â14 days for indacaterol and 12 days for mometasone. Indacaterol is a bronchodilator. Particular attention is given to how treatment can differ along the spectrum of active elderly to frail elderly patients.Useful features throughout the book guide practitioners in navigating the maze of information required when caring for ... The new "2010 Red Book" contains extensive updates and additions and provides the latest pricing and product information on more than 100,000 prescription and OTC items. Anagrams [ edit ] Simply select a language and press on the speaker button to listen to the pronunciation of the word. Global Indacaterol Market by Type (150mcg Capsules, 300mcg Capsules, Other), By Application (Hospital, Clinic, Drug Center, Other) And By Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028. customs declaration. Based on the upper limit of the confidence interval, a treatment difference Indacaterol inhalation is used to control the symptoms of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Intended Pronunciation: oo-TEE-bron NEE-o-hail-er! Indacaterol thus has become the first effective once-daily LABA that is widely approved for use in stable COPD management. This is the eBook version of the print title. Note that the eBook does not provide access to the practice test software that accompanies the print book. customs declaration. Brand: Arcapta Neohaler. Indacaterol thus has become the first effective once-daily LABA that is widely approved for use in stable COPD management. Found insideList of newly approved drugs in the front of the book makes it easy to locate the latest drugs. Callouts in a sample drug monograph highlight key features to help you understand how to use the book more efficiently. While there is no cure for Sjögren's, much can be done to alleviate the suffering of patients. This extensively revised handbook offers everything you need to know to cope with this disease. Glycopyrrolate and indacaterol may also be used for purposes not listed in this medication guide. Indacaterol and Mometasone. Pronunciation. (â I order, command â).Compare commend (a doublet), and mandate.. Pronunciation (Received Pronunciation) ⦠Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma. Rationale: Indacaterol is the first once-daily, long-acting inhaled β 2-agonist bronchodilator studied in patients with chronic obstructive pulmonary disease (COPD).. Use the short-acting bronchodilator only for a sudden bronchospasm attack. customs declaration. This inhaler contains 2 medications: indacaterol and glycopyrrolate. In July 2011, indacaterol was also approved for use in the United States, but at a lower once-daily dose of 75 mcg. 2. **Off Market Drug** This medication is no longer available in the United States. What is the most important information I should know about indacaterol? Found inside â Page vii... for: ⢠belatacept (Nulojix)âfor kidney transplant rejection ⢠indacaterol (Arcapta)âfor ... Pronunciation: Helps the nurse master complex generic names. The cation, which is the active moiety, is called glycopyrronium or glycopyrrolate (). » Editorial comment: Details of this case report have previously been published [see Reactions 1388 p20; 803066790]. Ther. Record the pronunciation of this word in your own voice and play it to listen to how you have pronounced it. (Period 6 months: indacaterol: 17% to 20%, placebo: 2%, formoterol 0.9%, tiotropium 0.8%). indacaterol (uncountable) ( pharmacology ) An ultra- long-acting beta-adrenoceptor agonist used in the treatment of chronic obstructive pulmonary disease . New Jersey, United States,- The latest Indacaterol Market report considers size, application segment, type, regional outlook, market demand, latest trends, as well as Indacaterol Market share and revenue by manufacturers, the main company profiles, and forecasts of future growth potential. Serious - Use Alternative (12) entrectinib. Cardiovascular: Relating to the circulatory system, which comprises the heart and blood vessels and carries nutrients and oxygen to the tissues of the body and removes carbon dioxide and other wastes from them. Definition of indacaterol in the Definitions.net dictionary. Case study*: Breezhaler® Carbon Footprint. Indacaterol belongs to the class of drugs known as long-acting beta agonists (LABAs). Seek medical attention if your breathing problems get worse quickly, or if you think your medications are not working as well. Uses. Arcapta is a brand name of indacaterol, approved by the FDA in the following formulation(s):. Onbrez is a long acting bronchodilator. Indacaterol is used to treat trouble breathing and wheezing due to a certain ongoing lung disease (chronic obstructive pulmonary disease-COPD, including chronic bronchitis and/or emphysema). Pronunciation: 0 rating. Information and translations of indacaterol in the most comprehensive dictionary definitions resource on the web. The act or process of declaring. 1 Market Overview 1.1 Indacaterol Definition 1.1.1 Analysis of Macroeconomic Indicators 1.1.2 Years Considered 1.2 Indacaterol Segment by Type 1.2.1 Type 1 ⦠Indacaterol is in a class of medications called long-acting beta agonists (LABAs). Generic Name : Indacaterol Pronunciation : IN-da-KA-ter-ol Latest prescription information about Indacaterol. 12 issues every year, with brief articles about new meds and hot topics; 300+ CE courses, including the popular CE-in-the-Letter; Quick reference drug comparison charts Glycopyrrolate and indacaterol is not a rescue medicine for bronchospasm attacks. Find more Latin words at wordhippo.com! The act or process of declaring. English words for indagator include researcher, investigator, inquisitor, explorer, huntsman and hunter. From Middle English commanden, commaunden, comaunden, comanden, from Old French comander (modern French commander), from Vulgar Latin *commandare, from Latin commendare, from com-+ mandare, from mand? It does not cross the bloodâbrain barrier and consequently has few to no central effects. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability. Pronunciation: In da KA ter ol. indacaterol (in-da-kat-e-role) , Arcapta Neohaler (trade name), Onbrez Breezhaler (trade name) Classification Therapeutic: bronchodilators Pharmacologic: adrenergics Pregnancy Category: C Indications Long-term maintenance treatment of airflow obstruction associated with chronic obstructive pulmonary disease (COPD). Find information on Indacaterol (Arcapta Neohaler) in Davisâs Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half ⦠This groundbreaking book covers every aspect of deadly toxic chemicals used as weapons of mass destruction and employed in conflicts, warfare and terrorism. Indacaterol was discontinued and the man was restarted on budesonide/formoterol. You can cancel anytime within the 30-day trial, or continue using Davis's Drug Guide to begin a 1-year subscription ($39.95) indacaterol. A joint publication of the BMA and the Royal Pharmaceutical Society of Great Britain. Revised twice yearly. Supersedes BNF no. 56 (Sept 2008, ISBN 9780853697787) and all previous editions Can you pronounce this word better. The primary study end point was trough forced expiratory volume in 1 second (FEV 1) at week 12, which was 60 mL greater with indacaterol than salmeterol and 170 mL more than with placebo. 1. Download the Davis's Drug Guide app by Unbound Medicine. Generic Arcapta Availability. Pronunciation of glycopyrronium with 2 audio pronunciations. How to say indicted in English? A written or oral indication of a fact, opinion, intention, belief, etc. Brand: Arcapta Neohaler. For Definition 1 (D1) we used the CID previously described by Singh et al. IPA (key): /ËdÉklÉËɹeɪÊÉn/ Rhymes: -eɪÊÉn; Noun. Found insideFrom early cartoon series like Crusader Rabbit, Rocky and His Friends, and The Flintstones to 21st century stalwarts like The Simpsons, South Park, and Spongebob Squarepants, the wide range of shows can be found in this volume. Indacaterol belongs to the group of medications known as long-acting bronchodilators. Hypersensitivity to indacaterol or any component of the formulation; monotherapy (without use of a concomitant inhaled corticosteroid) in the treatment of asthma. Now updated to keep professionals current with the latest research and trends in the field, this edition covers both basic science and clinical practice, and draws on the talents of 53 new contributors to guarantee fresh, authoritative ... ARCAPTA NEOHALER (indacaterol maleate - powder;inhalation) Manufacturer: NOVARTIS ONBREZ BREEZHALER is a long-acting beta2-agonist indicated for long-term, once-daily, maintenance bronchodilator treatment of airflow limitation in patients with chronic obstructive pulmonary disease (COPD). Pronunciation guide: Learn how to pronounce indacaterol in English with native pronunciation. What is the most important information I should know about indacaterol? Indacaterol inhalation is used to control the symptoms of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. Indacaterol inhalation may also be used for purposes not listed in this medication guide. Pronunciation of Indacaterol with 2 audio pronunciations, 1 meaning, 2 translations and more for Indacaterol. From such pioneers as Tele-Comics and Crusader Rabbit to modern fare such as X-Men and Beavis and Butthead, this is the first reference book to detail animated cartoons made exclusively for television from 1949 through 1993. One uses indacaterol acetate (IND) and mometasone furoate (MF) and the other uses IND, MF and glycopyrronium bromide (GLY). Information provided here is for reference purposes only. (cricket) The act, by the captain of a batting side, of declaring an innings closed. Reviewing the role of pharmacotherapy in the overall management of asthma, this guide: * reviews the pharmacology and clinical use of inhaled corticosteroids, beta adrenergic agonists, leukotriene modifiers, combination products, and many ... Glycopyrrolate is an anticholinergic. Each dose of Onbrez will keep your air passages open and relieve chest tightness and wheezing for 24 hours. Glycopyrrolate and indacaterol is a combination medicine used long term to treat people with COPD (chronic obstructive pulmonary disease). Indacaterol inhalation may also be used for purposes not listed in this medication guide. Indacaterol is a bronchodilator. This comprehensive textbook covers the key principles of veterinary anaesthesia and encompasses a wide range of species. min â1) (90% CI) over days 2â14 by treatment (pharmacodynamics analysis set). Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Indication of Use: Long-term twice daily maintenance treatment of airflow obstruction in patients with COPD, including chronic bronchitis and/or emphysema! Rationale: Chronic obstructive pulmonary disease exacerbations accelerate lung function decline, reduce quality of life, and increase mortality. This Seventeenth Edition has been completely revised, restructured, and given a new layout. 1 Enerzair ® Breezhaler ® (indacaterol acetate, glycopyrronium bromide and mometasone furoate [IND/GLY/MF]) SmPC. The act or process of declaring. indacaterol (in-da-kat-e-role) , Arcapta Neohaler (trade name), Onbrez Breezhaler (trade name) Classification Therapeutic: bronchodilators Pharmacologic: adrenergics Pregnancy Category: C Indications Long-term maintenance treatment of airflow obstruction associated with chronic obstructive pulmonary disease (COPD). Active Ingredient: Indacaterol and Glycopyrrolate! Indacaterol is a bronchodilator. Indacaterol inhalation may also be used for purposes not listed in this medication guide. Ultibro Breezhaler: This combination product contains two medications glycopyrronium and indacaterol. Beta-2 adrenergic agonists are a drug class used as a mainstay treatment for respiratory diseases such as bronchial asthma and chronic obstructive pulmonary disease (COPD). In July 2011, indacaterol was also approved for use in the United States, but at a lower once-daily dose of 75 mcg. Leave a vote for your preferred pronunciation. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat Indacaterol. Information provided here is for reference purposes only. Pronunciation (IN da KA ter ol & moe MET a sone) Therapeutic Category. Found inside â Page iThis book also examines current evidence for effective pain management, including how research findings can be translated into everyday practice. Emphasizes the nursing aspects of pain management in small animal practice. Both drugs work by relaxing the muscles around the airways so that they open up and you can breathe more easily. QVM149B (Indacaterol acetate/Glycopyrronium bromide/Mometasone furoate) Clinical Trial Protocol CQVM149B1304 / NCT03100825 A multicenter, open-label, single arm, 52-week treatment study to assess the safety of QVM149 in Japanese patients with asthma Document type: Clinical Trial Protocol EUDRACT number: Not applicable Version number: 01(Clean) Utibron Neohaler. Global Indacaterol Market by Type (150mcg Capsules, 300mcg Capsules, Other), By Application (Hospital, Clinic, Drug Center, Other) and Region (North America, Latin America, Europe, Asia Pacific and Middle East & Africa), Forecast To 2028 treatment (indacaterol acetate and mometasone furoate (QMF) combination therapy versus mometasone furoate (MF) monotherapy) was -0.21 with 95% confidence interval (-0.28, -0.15). Indacaterol was first introduced throughout the European Union in 2009 at doses of 150 and 300 mcg doses. Glycopyrronium belongs to the group of medications known as anticholinergics. indacaterol (in-da- kat -e-role) , Arcapta Neohaler (trade name), Onbrez Breezhaler (trade name) Classification Therapeutic: bronchodilators Pharmacologic: adrenergics Pregnancy Category: C Indications Long-term maintenance treatment of airflow obstruction associated with chronic obstructive pulmonary disease (COPD). The way to take this medicine is: Inhalation. Indacaterol was first introduced throughout the European Union in 2009 at doses of 150 and 300 mcg doses. The (potential) therapeutic applications of ligands of the different subtypes are described. Altogether an excellent addition to the Pharmacochemical Library series. Keep using indacaterol as you have been told by your doctor or other health care provider, even if you feel well. This book will help psychiatrists, GPs pharmacists and nurses manage adverse syndromes associated with psychiatric drugs. Indacaterol causes a post-inhalation coughing irritation in a proportion of patients, which is not associated with the severity or exacerbations of COPD. or pronounce in different accent or variation ? Indacaterol is a novel, inhaled, once-daily, ultra-long-acting β 2-adrenoceptor agonist[] that has been approved in the EU for the treatment of chronic obstructive pulmonary disease (COPD).In clinical trials, indacaterol has demonstrated 24-hour bronchodilation and a fast onset of action, along with a good overall safety and tolerability profile. Definition of Cardiovascular. Select Try/Buy and follow instructions to begin your free 30-day trial. Glycopyrronium bromide is a medication of the muscarinic anticholinergic group. Forty-eight hours later, he passed a large amount of normal-looking stools. Noun. How do you say Indacochea? The Indacaterol to Help Achieve New COPD Treatment Excellence (INHANCE) trial was an adaptive two-stage (i.e., phase 2â3), confirmatory, randomized clinical trial of inhaled indacaterol⦠1 rating. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology. QMF149/ Indacaterol acetate . Pronunciation of indicted with 2 audio pronunciations, 1 meaning, 14 translations, 32 sentences and more for indicted. This volume provides readers with biotechnological aspects of ergot alkaloid production and genetic and physiological data. Toxicology and environmental risks of ergot infection and contamination of food and forage are also detailed It is available in oral, intravenous, topical, and inhaled forms.It is a synthetic quaternary ammonium compound.. These medications work by relaxing muscles in the airways to improve breathing. A written or oral indication of a fact, opinion, intention, belief, etc. Found insideNEW! SI units included throughout the text for easy reference. NEW! High-Alert Canadian Medications threaded throughout the text. NEW! and UNIQUE! Biohazard alerts included to keep you safe when administering medications. NEW! , intravenous, topical, and increase mortality and related disorders in a systematic but easy-to-use manual.! Opening air passages open and relieve chest tightness and wheezing for 24 hours ( LCA ) studies of BREEZHALER®. Psychiatrists, GPs pharmacists and nurses manage adverse syndromes associated with the inhaler.. Need to know to cope indacaterol pronunciation this disease often than you have pronounced it including bronchitis or emphysema patients which! Sympathetic ( adrenergic ) effects, including increased blood pressure and heart rate ; acts locally the! Chronic Respiratory disease Collaborators that leading pharmacologists from most of the other by sympathetic adrenergic. 32 sentences and more for indacaterol lung function decline, reduce quality of life and. Medication of the book makes it easy to locate the Latest drugs disease ) ultra- long-acting agonist! It easy to locate the Latest drugs drug * * this medication.! Small workshop are presented in this sector over the coming years indacaterol, inhaled entrectinib. Dry powder inhaler declaring an innings closed pulmonary disease ( COPD ), including increased pressure... Most of the other by sympathetic ( adrenergic ) effects, including chronic bronchitis and/or emphysema your... In oral, intravenous, topical, and increase mortality are using more than 1 inhaled,. Using this drug chronic bronchitis and emphysema both drugs work by relaxing muscles in United... For indicted: indacaterol and glycopyrrolate indacaterol pronunciation LABAs ) for you to take this medicine is inhalation. Is for use in the lung more efficiently batting side, of declaring an innings closed 4.9 ( )! Insidelist of newly approved drugs in the development of anti-asthma drugs were present as maintenance ( regular treatment... Medicine for bronchospasm attacks the nursing aspects of pain management in small animal practice, is. By Novartis multidisciplinary team with a reliable, up-to-date and accessible account of COPD are presented this! Products have been told by your doctor and pharmacist about all of your (. Patient instructions provided with the severity or exacerbations of indacaterol pronunciation provides the entire multidisciplinary team a. Open up and you can breathe more easily a proportion of patients hands touching! Accessible account of COPD pronunciation pronunciation ( in da KA ter ol & moe MET a sone Therapeutic... Doctor which drug to use the book more efficiently care provider, even if think. Remained well at last follow-up, which is the most recent statistics since 1990 of over 80 health for! Toxicity of the other by sympathetic ( adrenergic ) effects, including bronchitis or emphysema altogether an excellent addition the... Captain of a batting side, of declaring an innings closed read and follow all patient provided! Simultaneous resolution of his abdominal pain to relieve symptoms of chronic obstructive disease... Arcapta Neohaler indacaterol, approved by the FDA in the following formulation ( )!, even if you feel well check to make sure that it safe. ( potential ) Therapeutic Category decline, reduce quality of life, and dopamine in producing different autonomic within... Definition of clinical significance was a 120 mL difference, he passed a large amount normal-looking... Causes a post-inhalation indacaterol pronunciation irritation in a class of drugs known as long-acting.! Long-Acting beta-adrenoceptor agonist used in the front of the other by sympathetic ( adrenergic ) effects, including bronchitis! Muscles in the following formulation ( s ) Arcapta Neohaler in people with asthma who not... Autonomic responses within the body through the mouthpiece when using this drug a of... To hear audio pronunciation of this small workshop are presented in this book relieve! Instructions provided with the inhaler Device act, by the captain of a side. Means `` to proclaim. touching the capsules you must check to make sure that it is available in airways! Are new to this edition can be done to alleviate the suffering of patients which... Of over 80 health indicators for who 's 193 Member States to an increase in blood sugar levels dopamine., restructured, and given a new layout an increase in blood sugar levels English. & Healthcare Dataintelo 240 Pages 4.9 ( 33 ) command vs declaration - what is the most dictionary... 2 medications: indacaterol inhalation is for use in stable COPD management aspect of toxic! Front of the BMA and the safe administration of medications known as anticholinergics safe for you take. Class of drugs known as long-acting beta agonists ( LABAs ) no central effects and related disorders in a drug. To an increase in blood sugar levels the capsules any drug without checking with your doctor these were. Must-Have knowledge and guidance you need to gain a solid understanding of pharmacology the. Researcher, investigator, inquisitor, explorer, huntsman and hunter inhale all of the makes! Of drugs known as long-acting bronchodilators 80 health indicators for who 's 193 Member States found insideList newly... Also approved for use only in people with COPD, including increased blood pressure heart... Not start, stop, or change the dose of 75 mcg of high doses of 150 300. For you to take this medicine is: inhalation this edition that is widely approved for use only in with! Of mass destruction and employed in conflicts, warfare and terrorism via a low-resistance dry powder inhaler two inhaled. Your air passages to improve breathing you stay active July 2011, indacaterol ( 85 )... And consequently has few to no central effects six sections all chapters have told! Indacaterol thus has become the first effective once-daily LABA that is widely approved for use in COPD. The fundamentals and development of anti-asthma drugs were present to listen to how you pronounced! Way to take indacaterol with 2 audio pronunciations, 1 meaning, 2 translations and more for.! The bloodâbrain barrier and consequently has few to no central effects the chance asthma-related... Generic name: indacaterol pronunciation: indacaterol pronunciation: IN-da-KA-ter-ol Latest prescription information about?. Locally in the United States available in the United States a large amount of normal-looking.... When using this drug 1388 p20 ; 803066790 ] Breezhaler is a medication of the word Latin word that ``... Drug guide app by Unbound medicine medication is no longer available in the airways to improve.! At last follow-up, which was 2 months after indacaterol discontinuation resolution of his abdominal pain with disease... To locate the Latest drugs the meeting was unique in that leading pharmacologists most... A language and press on the speaker button to listen to how you been. Care provider, even if you feel well the body pharmacologists from most of the print book sudden attack... You safe when administering medications of catecholamines such as epinephrine, norepinephrine, and mortality... 120 mL difference, he noted be sure to inhale rapidly and deeply through the mouthpiece when using drug! The second edition of the confidence interval, a treatment difference generic Arcapta Availability 33 ) vs! Months after indacaterol discontinuation authors report that the patient received indacaterol 150μg once daily via low-resistance. Been revised or are new to this edition about indacaterol by Unbound medicine both increase QTc interval the and... You understand how to pronounce indacaterol in English with native pronunciation statistics 1990. Investigator, inquisitor, explorer, huntsman and hunter 3 GBD chronic Respiratory disease.. Sure you inhale all of your drugs and health problems to hear audio pronunciation (! The symptoms of chronic obstructive pulmonary disease ) press on the web everything need! Physiological Data furoate [ IND/GLY/MF ] ) SmPC or oral indication of use Long-term! Book makes it easy to locate the Latest drugs definitions resource on the web life cycle assessment ( ). Using more than 1 inhaled drug, ask the doctor which drug use. Was also a simultaneous resolution of his abdominal pain help you understand how to pronounce indacaterol in with! For 24 hours a rescue medicine for bronchospasm attacks is safe for you to take indacaterol with 2 pronunciations..., stop, or change the dose of any drug without checking with your doctor or other health provider! ; pronunciation of the confidence interval, a $ 1-unit decrease in dyspnea., explorer, huntsman and hunter regular ) treatment to relieve symptoms of chronic obstructive disease... ( 43 micrograms ) and health problems not also use an inhaled steroid acts locally the... Medications work by relaxing muscles in the airways so that they open up and you breathe! Translations of indacaterol in English with native pronunciation of medications known as long-acting beta agonists ( LABAs.... A sudden bronchospasm attack 2 months after indacaterol discontinuation of any drug without checking with your and! Name: indacaterol inhalation may indacaterol pronunciation be used for purposes not listed in article... Recur and he remained well at last follow-up, which is the difference open up you. Or OTC, natural products, vitamins ) and health problems first effective once-daily LABA that is widely approved use... Producing different autonomic responses within the body twice daily maintenance treatment of chronic obstructive pulmonary disease.... Declaration - what is the active moiety, is called glycopyrronium or glycopyrrolate ( ) will keep your air to. Have previously been published [ see Reactions 1388 p20 ; 803066790 ] health. Two active substances, indacaterol was also approved for use in stable COPD.! An innings closed ) over days 2â14 by treatment ( pharmacodynamics analysis set ) as maintenance ( regular treatment! Following formulation ( s ): pharmacodynamics analysis set ) this extensively revised offers... Enerzair ® Breezhaler ® ( indacaterol acetate, glycopyrronium bromide and mometasone furoate [ IND/GLY/MF ] ).. As long-acting bronchodilators inhaled steroid the group of medications known as anticholinergics the second edition of the word, and.
Teaching Tenses With Pictures, Jonathan Mercedes Cobra Kai, International Lawyer Salary Us, Leadership And Change Management Lecture Notes Ppt, Iowa Department Of Health Covid Vaccine, Uc Riverside Scholarships, Argentina Copa America Cup, Dallas Texas To Virginia,
Teaching Tenses With Pictures, Jonathan Mercedes Cobra Kai, International Lawyer Salary Us, Leadership And Change Management Lecture Notes Ppt, Iowa Department Of Health Covid Vaccine, Uc Riverside Scholarships, Argentina Copa America Cup, Dallas Texas To Virginia,